Uncovering the Secrets of DNA Methylation
Explore our groundbreaking research on DNA methylation and its profound impact on development and disease.
Advancing Research in DNA Methylation Studies
Welcome to the Gowher Lab. We study epigenetic mechanisms that control cell identity and determine how these mechanisms are disrupted in cancer and development. Our research specifically focuses on the activity of distal regulatory elements, called enhancers, and insulators of developmental genes by using mouse embryonic stem cells and embryonal carcinoma cells as model systems. In addition, we also study biochemical mechanism/s of DNA methyltransferases and the effect of mutations commonly found in cancer and other developmental disorders.
Recent Research Publications
Stay updated with our latest research findings.
Norvil AB*, Petell CJ**, Alabdi LA**, Wu L*, Rossie S, Gowher H. Dnmt3b methylates DNA by a non-cooperative mechanism and its activity is unaffected by manipulations at the predicted dimer interface. Biochemistry 2016 Nov 4th. Impact Factor: 3.0
Norvil AB**, AlAbdi L**, Liu B***, Forstoffer NE*, Michie AR*, Chen T, Gowher H. The Acute Myeloid Leukemia variant DNMT3A Arg882His is a DNMT3B-like enzyme. Nucleic Acids Res. 2020 Apr 17;48(7):3761-3775. Impact Factor: 11.2
AlAbdi L**, Saha D***, He M***, Dar MS***, Utturkar SM, Sudyanti PA**, McCune S*, Spears BH*, Breedlove JA*, Lanman NA, Gowher H. Oct4 mediated inhibition of Lsd1 activity promotes the active and primed state of pluripotency enhancers. 2020 Cell Reports 30 (5), 1478-1490. Impact Factor: 7.8
Norvil AB**, Saha D***, Saleem Dar M***, Gowher H. Effect of Disease-Associated Germline Mutations on Structure Function Relationship of DNA Methyltransferases. Genes (Basel). 2019 May 14;10(5).Impact Factor: 3.3
